Article
Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families.
American journal of human genetics - 1 Aug 2004
Fallin M Daniele, Lasseter Virginia K, Wolyniec Paula S, McGrath John A, Nestadt Gerald, Valle David, Liang Kung-Yee, Pulver Ann E
Abstract excerpt
The relatively short history of linkage studies in bipolar disorders (BPs) has produced inconsistent findings. Implicated regions have been large, with reduced levels of significance and modest effect sizes. Both phenotypic and genetic heterogeneity may have contributed to the failure to define risk loci. BP is part of a spectrum of apparently familial affective disorders, which have been organized by severity....
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