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Article

Linkage analysis of complex disorders with multiple phenotypic categories: simulation studies and application to bipolar disorder data.

Genetic epidemiology - 1 Jan 1997

Levinson D F

Abstract excerpt

The problem of linkage analysis of disorders with multiple possible phenotypes (diagnostic spectrum) is considered. A modification is proposed to Ott's [1994] method of down-weighting the contribution of broader diagnoses by reducing penetrance ratios for affected cases. A "robust weighting" strategy considers only the robustness of a set of ratios across a range of true genetic models. Practical models for...

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PMID: 9433558
DOI: 10.1002/(SICI)1098-2272(1997)14:6<653::AID-GEPI17>3.0.CO;2-P

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Source receipt: pubmed, retrieved 7 Sept 2026.

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