Linkage analysis of complex disorders with multiple phenotypic categories: simulation studies and application to bipolar disorder data.

doi:10.1002/(SICI)1098-2272(1997)14:6<653::AID-GEPI17>3.0.CO;2-P

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Article

Linkage analysis of complex disorders with multiple phenotypic categories: simulation studies and application to bipolar disorder data.

Genetic epidemiology - 1 Jan 1997

Levinson D F

Abstract excerpt

The problem of linkage analysis of disorders with multiple possible phenotypes (diagnostic spectrum) is considered. A modification is proposed to Ott's [1994] method of down-weighting the contribution of broader diagnoses by reducing penetrance ratios for affected cases. A "robust weighting" stra...

Topics

Bipolar Disorder
Computer Simulation
Genetic Heterogeneity
Genetic Linkage
Humans
Lod Score
Models, Genetic
Models, Statistical
Penetrance
Phenotype
Statistics, Nonparametric

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