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Article

Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network.

Genome research - 1 Jul 2008

Iossifov Ivan, Zheng Tian, Baron Miron, Gilliam T Conrad, Rzhetsky Andrey

Abstract excerpt

Common hereditary neurodevelopmental disorders such as autism, bipolar disorder, and schizophrenia are most likely both genetically multifactorial and heterogeneous. Because of these characteristics traditional methods for genetic analysis fail when applied to such diseases. To address the problem we propose a novel probabilistic framework that combines the standard genetic linkage formalism with whole-genome...

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Identifiers

PMID: 18417725
DOI: 10.1101/gr.075622.107
PMCID: PMC2493404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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