Article
A tree-based model for allele-sharing-based linkage analysis in human complex diseases.
Genetic epidemiology - 1 Feb 2006
Xu W, Schulze T G, DePaulo J R, Bull S B, McMahon F J, Greenwood C M T
Abstract excerpt
By adapting a well-known affected-relative-pair linkage model that can incorporate covariate or sub-phenotype information [Olson, 1999: Am J Hum Genet 65:1760-1769], we have developed a recursive-partitioning (RP) algorithm (tree-based model) for identifying phenotype and covariate groupings that interact with the evidence for linkage. This strategy is designed to identify subgroups of affected relative pairs...
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