Article
Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees.
Biological psychiatry - 1 Dec 2003
McInnis Melvin G, Dick Danielle M, Willour Virginia L, Avramopoulos Dimitrios, MacKinnon Dean F, Simpson Sylvia G, Potash James B, Edenberg Howard J, Bowman Elizabeth S, McMahon Francis J, Smiley Carrie, Chellis Jennifer L, Huo Yuqing, Diggs Tyra, Meyer Eric T, Miller Marvin, Matteini Amy T, Rau N Leela, DePaulo J Raymond, Gershon Elliot S, Badner Judith A, Rice John P, Goate Alison M, Detera-Wadleigh Sevilla D, Nurnberger John I, Reich Theodore, Zandi Peter P, Foroud Tatiana M
Abstract excerpt
BACKGROUND: In 1989 the National Institute of Mental Health began a collaborative effort to identify genes for bipolar disorder. The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied. METHODS: Three hierarchical affection status models were analyzed...
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