Probabilistic diagnosis in linkage analysis of bipolar disorder: putting weights on the fringe.

doi:10.1002/(SICI)1098-2272(1997)14:6<693::AID-GEPI24>3.0.CO;2-K

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Article

Probabilistic diagnosis in linkage analysis of bipolar disorder: putting weights on the fringe.

Genetic epidemiology - 1 Jan 1997

Van Eerdewegh P, Santangelo S L, Lee H, Laird N M, Blacker D

Abstract excerpt

We explored the utility of probabilistic weighting of fringe phenotypes in linkage analysis of bipolar disorder for the GAW10 chromosome 18 data. Four liability classes were assigned probabilistic weights based on the estimated probability that the case was a true bipolar. The weights were incorp...

Topics

Bipolar Disorder
Chromosomes, Human, Pair 18
Genetic Linkage
Humans
Lod Score
Models, Genetic
Models, Statistical
Phenotype
Prevalence
Probability
Risk Factors
Statistics, Nonparametric

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