Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relevance of TP53 for CLL diagnostics

2 Feb 2019

Abstract excerpt

TP53 disruption in chronic lymphocytic leukaemia (CLL) is a well-established prognostic marker and informs on the appropriate course of treatment for patients. TP53 status is commonly assessed by fluorescence in situ hybridisation for del(17 p) and Sanger sequencing for TP53 mutations. At present, current screening methods for TP53 mutations fail to detect diagnostically relevant mutations potentially leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Chronic Lymphocytic Leukemia Research
Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30712002
DOI: 10.1136/jclinpath-2018-205622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relevance of TP53 for CLL diagnosticsPMID 30712002Read ↗

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update.Semantic proximity Read ↗

ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia.Semantic proximity Read ↗

Recent advances in the understanding of TP53 in haematological malignancies.Semantic proximity Read ↗

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretationSemantic proximity Read ↗

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignanciesSemantic proximity Read ↗

Targeting the p53 Pathway in CLL: State of the Art and Future PerspectivesSemantic proximity Read ↗

Gene mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?Semantic proximity Read ↗

The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.Semantic proximity Read ↗

The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target.Semantic proximity Read ↗

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.Semantic proximity Read ↗

The clinical implications of gene mutations in chronic lymphocytic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.