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Article

p53 protein expression in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Jul 2012

Sellmann Ludger, Carpinteiro Alexander, Nückel Holger, Scholtysik René, Siemer Dörte, Klein-Hipass Ludger, Kube Dieter, Dürig Jan, Dührsen Ulrich, Stanelle Jens, Küppers Ralf

Abstract excerpt

Alterations in the function of the p53 pathway are frequently described in chronic lymphocytic leukemia (CLL), mostly associated with deletion of 17p13 and/or mutations of the TP53 gene. In the present study, we investigated 103 CLLs for the impact of protein expression of full-length p53 and its isoforms β and γ. A strong correlation between deletions of 17p13 and an accumulation of full-length p53 protein was...

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Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to In Situ Hybridization, Fluorescence

Share to Kaplan-Meier Estimate

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Protein Isoforms

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 22220854
DOI: 10.3109/10428194.2011.654115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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