Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics.

doi:10.1016/s0165-4608(96)00341-x

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Article

Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics.

Cancer genetics and cytogenetics - 1 Sept 1997

Amiel A, Arbov L, Manor Y, Fejgin M, Elis A, Gaber E, Lishner M

Abstract excerpt

Chromosomal aberrations can be detected in 50% of patients with chronic lymphocytic leukemia (CLL). A role for tumor suppressor genes in the genesis of lymphoid tumors has been reported. In B-CLL, p53 gene mutations were found in 10-15% of the patients. We used fluorescence in situ hybridization...

Topics

Aged
Alleles
Cytogenetics
Female
Gene Deletion
Genes, p53
Humans
In Situ Hybridization, Fluorescence
Interphase
Leukemia, Lymphocytic, Chronic, B-Cell
Leukocytes, Mononuclear
Male
Middle Aged

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