Article
Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics.
Cancer genetics and cytogenetics - 1 Sept 1997
Amiel A, Arbov L, Manor Y, Fejgin M, Elis A, Gaber E, Lishner M
Abstract excerpt
Chromosomal aberrations can be detected in 50% of patients with chronic lymphocytic leukemia (CLL). A role for tumor suppressor genes in the genesis of lymphoid tumors has been reported. In B-CLL, p53 gene mutations were found in 10-15% of the patients. We used fluorescence in situ hybridization (FISH) to detect p53 deletion in B-CLL. We also correlated the cytogenetic findings with the clinical course. In situ...
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