Article
K-ras and p53 gene mutations in colorectal cancer in 57 Japanese patients.
Fukushima journal of medical science - 1 Jun 1997
Onda M, Abe R, Tsuchiya A, Fukushima T, Ando Y, Yoshida T
Abstract excerpt
Fifty-eight tissue specimens from 57 Japanese patients with colorectal cancer were analyzed for the K-ras and p53 gene mutations by polymerase chain reaction-single strand conformation polymorphism analysis and direct sequencing. K-ras mutations were detected in 21 cases (36.2%) and p53 mutations in 20 cases (34.5%). Eight specimens had both gene mutations. The K-ras mutation was associated with higher degrees of...
Topics
- Adenocarcinoma
- Colorectal Neoplasms
- Female
- Genes, p53
- Genes, ras
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational