Presenilin-1 polymorphism in Alzheimer's disease and vascular dementia.

doi:10.1006/exnr.1997.6558

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Article

Presenilin-1 polymorphism in Alzheimer's disease and vascular dementia.

Experimental neurology - 1 Aug 1997

Matsushita S, Arai H, Muramatsu T, Makimoto K, Nakagawa T, Sasaki H, Higuchi S

Abstract excerpt

Recent reports suggest an association between an intronic polymorphism at the 3' position of exon 8 of the presenilin-1 (PS-1) gene and late-onset Alzheimer's disease (AD), but little is known about its role in the pathogenesis of AD. By genotyping 193 Japanese patients with vascular dementia or...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Dementia, Vascular
Gene Frequency
Genotype
Humans
Membrane Proteins
Polymorphism, Genetic
Presenilin-1
Reference Values

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