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Article

Apolipoprotein E allele distribution in parents of Down's syndrome children.

Lancet (London, England) - 30 Mar 1996

Avramopoulos D, Mikkelsen M, Vassilopoulos D, Grigoriadou M, Petersen M B

Abstract excerpt

BACKGROUND: An increased risk of Alzheimer's disease (AD) has been reported in young mothers of Down's syndrome (DS) probands. Allele epsilon4 of the apolipoprotein E (apoE) gene is a genetic susceptibility factor for AD. We examined the distribution of apoE alleles in people with DS and their pa...

Topics

Adult
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
Denmark
Down Syndrome
Female
Gene Frequency
Humans
Infant, Newborn
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Maternal Age

Meiosis

Nondisjunction, Genetic

Paternal Age

Polymorphism, Genetic

Source

Identifiers

PMID: 8622392
DOI: 10.1016/s0140-6736(96)91346-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8622392-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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