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Article

Apolipoprotein E allele distribution in parents of Down's syndrome children.

Lancet (London, England) - 30 Mar 1996

Avramopoulos D, Mikkelsen M, Vassilopoulos D, Grigoriadou M, Petersen M B

Abstract excerpt

BACKGROUND: An increased risk of Alzheimer's disease (AD) has been reported in young mothers of Down's syndrome (DS) probands. Allele epsilon4 of the apolipoprotein E (apoE) gene is a genetic susceptibility factor for AD. We examined the distribution of apoE alleles in people with DS and their parents. METHODS: We studied 188 Danish people with non-mosaic free trisomy 21 of known parental origin (determined by...

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Identifiers

PMID: 8622392
DOI: 10.1016/s0140-6736(96)91346-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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