Article
Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.
Development (Cambridge, England) - 1 Aug 1998
Yang Y, Guillot P, Boyd Y, Lyon M F, McMahon A P
Abstract excerpt
Patterning of the vertebrate limb along the anterior-posterior axis is controlled by the zone of polarizing activity (ZPA) located at the posterior limb margin. One of the vertebrate Hh family members, Shh, has been shown to be able to mediate the function of the ZPA. Several naturally occurring...
Topics
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins
- Embryonic Induction
- Extremities
- Fibroblast Growth Factor 4
- Fibroblast Growth Factors
- Gene Expression Regulation
- Hedgehog Proteins
- Homeodomain Proteins
- Homozygote
- In Situ Hybridization
- Mice
- Mice, Inbred Strains
- Mutation
- Polydactyly
- Proteins
- Proto-Oncogene Proteins