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Article

Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch.

Current biology : CB - 28 Jan 1999

Sharpe J, Lettice L, Hecksher-Sorensen J, Fox M, Hill R, Krumlauf R

Abstract excerpt

The mouse mutants of the hemimelia-luxate group (lx, lu, lst, Dh, Xt, and the more recently identified Hx, Xpl and Rim4; [1] [2] [3] [4] [5]) have in common preaxial polydactyly and longbone abnormalities. Associated with the duplication of digits are changes in the regulation of development of the anterior limb bud resulting in ectopic expression of signalling components such as Sonic hedgehog (Shh) and...

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PMID: 10021368
DOI: 10.1016/s0960-9822(99)80022-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch.PMID 10021368Read ↗

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Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.Semantic proximity Read ↗

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