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Article

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.

International journal of cancer - 19 Dec 1997

Breivik J, Lothe R A, Meling G I, Rognum T O, Børresen-Dale A L, Gaudernack G

Abstract excerpt

Mutations in the k-ras and TP53 genes, as well as microsatellite instability (MIN), are frequent genetic alterations in colorectal carcinomas and represent 3 different mechanisms in the carcinogenic process. Both the incidence of colorectal cancer and the frequency of genetic alterations in such tumours have been related to different clinico-pathological variables, including age and gender of the patient and...

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Identifiers

PMID: 9421366
DOI: 10.1002/(sici)1097-0215(19971219)74:6<664::aid-ijc18>3.0.co;2-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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