Article
Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas.
The Journal of molecular diagnostics : JMD - 1 May 2006
Sugai Tamotsu, Habano Wataru, Jiao Yu-Fei, Tsukahara Mitsunori, Takeda Yuichiro, Otsuka Koki, Nakamura Shin-ichi
Abstract excerpt
To clarify distinct genetic profiles of colorectal cancers based on tumor location (left- and right-sided), we evaluated the status of loss of heterozygosity (LOH), CpG islands methylation phenotype (CIMP), microsatellite instability (MSI), and mutations of p53, Ki-ras, and APC genes in 119 colorectal cancers. Statuses of LOH (at 5q, 8p, 17p, 18q, and 22q), MSI, and CIMP (MINT1, MINT2, MINT31, MLH-1, MGMT, p14,...
Topics
- Aged
- Aged, 80 and over
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Genes, APC
- Genes, ras
- Humans