Article
Colorectal cancers choosing sides.
Biochimica et biophysica acta - 1 Dec 2011
Albuquerque Cristina, Bakker Elvira R M, van Veelen Wendy, Smits Ron
Abstract excerpt
In contrast to the majority of sporadic colorectal cancer which predominantly occur in the distal colon, most mismatch repair deficient tumours arise at the proximal side. At present, these regional preferences have not been explained properly. Recently, we have screened colorectal tumours for mutations in Wnt-related genes focusing specifically on colorectal location. Combining this analysis with published data,...
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