Article
Different mechanisms in the tumorigenesis of proximal and distal colon cancers.
Current opinion in oncology - 1 Jan 2001
Lindblom A
Abstract excerpt
Environment or genetic constitutions can lead to an increase of genetic or epigenetic events and increase the risk for malignancy. Genomic instability is seen in most types of malignancies. Two forms of genetic instability have been described in colorectal cancer: chromosomal instability (CIN), and microsatellite instability (MIN). Almost all sporadic MIN tumors occur in the proximal colon, whereas most sporadic...
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