Article
Amino acid variation in the GyrA subunit of bacteria potentially associated with natural resistance to fluoroquinolone antibiotics.
Antimicrobial agents and chemotherapy - 1 Dec 1997
Waters B, Davies J
Abstract excerpt
In studies of genetic diversity in natural microbial populations, we have analyzed nucleotide sequences in the quinolone resistance-determining region of the bacterial gyrA gene in ciprofloxacin-resistant and nonselected soil bacteria obtained from the environment. It is apparent that this sequen...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Bacteria
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Genetic Variation
- Macromolecular Substances
- Molecular Sequence Data
- Polymerase Chain Reaction
- Sequence Homology, Amino Acid