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Article

Analysis by PCR and direct DNA sequencing of gyrA mutations associated with fluoroquinolone resistance in Enterococcus faecalis.

Antimicrobial agents and chemotherapy - 1 Sept 1994

Korten V, Huang W M, Murray B E

Abstract excerpt

A region of gyrA, the gene encoding subunit A of DNA gyrase, that is known to be associated with resistance was amplified and sequenced from 16 Enterococcus faecalis and Enterococcus faecium isolates. Six ciprofloxacin-resistant clinical isolates (MICs of ciprofloxacin, 32 to 64 micrograms/ml) and one multistep resistant laboratory mutant of E. faecalis (MIC of ciprofloxacin, 128 micrograms/ml) contained a change...

Topics

Amino Acid Sequence
Anti-Infective Agents
Base Sequence
Ciprofloxacin
DNA Gyrase
DNA Topoisomerases, Type II
DNA, Bacterial
Drug Resistance, Microbial
Enterococcus faecalis
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Sequence Analysis, DNA

Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7811024
DOI: 10.1128/AAC.38.9.2091
PMCID: PMC284689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7811024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis by PCR and direct DNA sequencing of gyrA mutations associated with fluoroquinolone resistance in Enterococcus faecalis.PMID 7811024Read ↗

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