Article
Molecular diversity of quinolone resistance in genetically related clinical isolates of Staphylococcus aureus and susceptibility to newer quinolones.
The Journal of antimicrobial chemotherapy - 1 Feb 2001
Guirao G Y, Martínez Toldos M C, Mora Peris B, Alonso Manzanares M A, Gutiérrez Zufiaurre M N, Martínez Andrés J A, Muñoz Bellido J L, García-Rodríguez J A, Segovia Hernández M
Abstract excerpt
The genes encoding topoisomerases (gyrA and grlA) and the norA promoter of 100 fluoroquinolone-susceptible and -resistant Staphylococcus aureus clinical isolates obtained in two geographically distant hospitals were analysed. The relationship between mutations found and the susceptibility to newer quinolones was determined. Thirty-nine strains were grouped in seven clones by pulsed-field gel electrophoresis...
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