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Article

Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals.

Antimicrobial agents and chemotherapy - 1 Apr 1996

Griggs D J, Gensberg K, Piddock L J

Abstract excerpt

The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser83-->Phe) and Asp87-->Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala119-->Glu. The data suggest that gyrA mutations are...

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Identifiers

PMID: 8849216
DOI: 10.1128/AAC.40.4.1009
PMCID: PMC163248

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