Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selection of antibiotic-resistant bacterial mutants: allelic diversity among fluoroquinolone-resistant mutations.

The Journal of infectious diseases - 1 Aug 2000

Zhou J, Dong Y, Zhao X, Lee S, Amin A, Ramaswamy S, Domagala J, Musser J M, Drlica K

Abstract excerpt

To obtain a general framework for understanding selection of antibiotic-resistant mutants, allelic diversity was examined with about 600 fluoroquinolone-resistant mutants of mycobacteria. Selection at low fluoroquinolone concentration produced many low-level resistance mutants. Some of these contained mutations that conferred unselected antibiotic resistance; none contained alterations in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type II

Share to Drug Resistance, Microbial

Share to Fluoroquinolones

Share to Mycobacterium

Share to Mycobacterium smegmatis

Share to Mycobacterium tuberculosis

Source

Identifiers

PMID: 10915083
DOI: 10.1086/315708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selection of antibiotic-resistant bacterial mutants: allelic diversity among fluoroquinolone-resistant mutations.PMID 10915083Read ↗

Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window.Semantic proximity Read ↗

Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success.Semantic proximity Read ↗

Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection.Semantic proximity Read ↗

Characterization of Mycoplasma hominis mutations involved in resistance to fluoroquinolones.Semantic proximity Read ↗

Antibiotic resistance in mycobacteria.Semantic proximity Read ↗

Dose-related selection of fluoroquinolone-resistant Escherichia coli.Semantic proximity Read ↗

Relative potential for selection of quinolone-resistance-determining-region mutations in Streptococcus pneumoniae by gemifloxacin, gatifloxacin and moxifloxacin.Semantic proximity Read ↗

In Vitro Derivation of Fluoroquinolone-Resistant Mutants from Multiple Lineages of Haemophilus influenzae and Identification of Mutations Associated with Fluoroquinolone Resistance.Semantic proximity Read ↗

In vitro evolution provides insights into mechanisms of Mycoplasma genitalium resistance to moxifloxacin.Semantic proximity Read ↗

Rifamycin resistance in mycobacteria.Semantic proximity Read ↗

Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients.Semantic proximity Read ↗

Selection of moxifloxacin-resistant Staphylococcus aureus compared with five other fluoroquinolones.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.