Article
gyrA mutations associated with quinolone resistance in Bacteroides fragilis group strains.
Antimicrobial agents and chemotherapy - 1 Jul 2001
Oh H, El Amin N, Davies T, Appelbaum P C, Edlund C
Abstract excerpt
Mutations in the gyrA gene contribute considerably to quinolone resistance in Escherichia coli. Mechanisms for quinolone resistance in anaerobic bacteria are less well studied. The Bacteroides fragilis group are the anaerobic organisms most frequently isolated from patients with bacteremia and intraabdominal infections. Forty-four clinafloxacin-resistant and-susceptible fecal and clinical isolates of the B....
Topics
- Amino Acid Substitution
- Anti-Infective Agents
- Aza Compounds
- Bacteroides fragilis
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Humans
- Levofloxacin