Article
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Aug 1991
Yoshida H, Bogaki M, Nakamura M, Yamanaka L M, Nakamura S
Abstract excerpt
Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that...
Topics
- Amino Acid Sequence
- Binding Sites
- Chemical Phenomena
- Chemistry, Physical
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Escherichia coli
- Molecular Sequence Data
- Mutation
- Quinolones