Article
Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii.
Antimicrobial agents and chemotherapy - 1 May 1995
Vila J, Ruiz J, Goñi P, Marcos A, Jimenez de Anta T
Abstract excerpt
The gyrA gene mutations associated with quinolone resistance were determined in 21 epidemiologically unrelated clinical isolates of Acinetobacter baumannii. Our studies highlight the conserved sequences in the quinolone resistance-determining region of the gyrA gene from A. baumannii and other bacteria. All 15 isolates for which the MIC of ciprofloxacin is > or = 4 micrograms/ml showed a change at Ser-83 to Leu....
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