Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function.

Oncogene - 4 Dec 1997

Cai Z, Capoulade C, Moyret-Lalle C, Amor-Gueret M, Feunteun J, Larsen A K, Paillerets B B, Chouaib S

Abstract excerpt

We have investigated the relationship between the development of tumor resistance towards the cytotoxic action of tumor necrosis factor-alpha (TNF) and p53 function, using the TNF-sensitive MCF7 human breast adenocarcinoma cell line and two TNF-resistant sublines, MCF7/R-A1 and MCF7/Adr. Use of single-strand conformation polymorphism (SSCP) analysis and DNA sequencing shows that MCF7 has a wild-type p53 gene,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Mutation

Share to Nuclear Proteins

Share to Proto-Oncogene Proteins

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9419972
DOI: 10.1038/sj.onc.1201445

Genes

TNF
MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function.PMID 9419972Read ↗

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.Semantic proximity Read ↗

The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.Semantic proximity Read ↗

Up-regulation of Fas (CD95) in human p53wild-type cancer cells treated with ionizing radiationSemantic proximity Read ↗

Lack of correlation between p53 protein level and sensitivity of DNA-damaging agents in keratinocytes carrying adenovirus E1a mutants.Semantic proximity Read ↗

Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cellsSemantic proximity Read ↗

Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.Semantic proximity Read ↗

Biological activity of mutants of human tumour necrosis factor-alpha.Semantic proximity Read ↗

Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance.Semantic proximity Read ↗

Genetically recessive mutant of human monocytic leukemia U937 resistant to tumor necrosis factor-alpha-induced apoptosis.Semantic proximity Read ↗

Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cellsSemantic proximity Read ↗

Transforming growth factor-beta1 resistance in a thyroid cancer model of tumor necrosis factor-alpha resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.