Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 1999

Sleijfer S, Le T K, de Jong S, Timmer-Bosscha H, Withoff S, Mulder N H

Abstract excerpt

Several studies suggest that tumor necrosis factor-alpha (TNF) is able to overcome drug resistance in tumors. Whether TNF is able to do so in tumor cell lines that are drug resistant due to a mutation in the tumor suppressor gene p53 is unclear. Therefore, we studied the in vitro cytotoxic effects of TNF combined with various cytotoxic agents in a model consisting of a human ovarian cancer cell line containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Survival

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to TNF gene

Share to Genes, p53

Share to Mutation

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9924699
DOI: 10.1097/00002371-199901000-00007

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.PMID 9924699Read ↗

Sensitivity of drug-resistant human ovarian tumor cell lines to combined effects of tumor necrosis factor (TNF-alpha) and doxorubicin: failure of the combination to modulate the MDR phenotype.Semantic proximity Read ↗

Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance.Semantic proximity Read ↗

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAILSemantic proximity Read ↗

Chemotherapy-induced apoptosis in melanoma cells is p53 dependent.Semantic proximity Read ↗

Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cellsSemantic proximity Read ↗

Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.Semantic proximity Read ↗

Cytostatic and cytotoxic effects of recombinant tumor necrosis factor-alpha on sensitive human melanoma cells in vitro may result in selection of cells with enhanced markers of malignancy.Semantic proximity Read ↗

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand and Chemotherapy Cooperate to Induce Apoptosis in Mesothelioma Cell LinesSemantic proximity Read ↗

p53-independent apoptosis induced by paclitaxel through an indirect mechanismSemantic proximity Read ↗

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function.Semantic proximity Read ↗

Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line.Semantic proximity Read ↗

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.