Article
Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 1999
Sleijfer S, Le T K, de Jong S, Timmer-Bosscha H, Withoff S, Mulder N H
Abstract excerpt
Several studies suggest that tumor necrosis factor-alpha (TNF) is able to overcome drug resistance in tumors. Whether TNF is able to do so in tumor cell lines that are drug resistant due to a mutation in the tumor suppressor gene p53 is unclear. Therefore, we studied the in vitro cytotoxic effect...
Topics
- Antineoplastic Agents
- Cell Survival
- Cisplatin
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Therapy, Combination
- Female
- Genes, p53
- Humans
- Melphalan
- Mitoxantrone
- Mutation
- Ovarian Neoplasms
- Paclitaxel
- Teniposide
- Transfection
- Tumor Cells, Cultured