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Article

Transforming growth factor-beta1 resistance in a thyroid cancer model of tumor necrosis factor-alpha resistance.

Thyroid : official journal of the American Thyroid Association - 1 Nov 1998

Pang X P, Hershman J M

Abstract excerpt

We have shown that both tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) inhibit the growth of the human papillary thyroid carcinoma (PTC) cell line, NPA. In previous work, we developed NPA cells that were resistant to the growth suppressive effect of TNF-alpha, called R30, R45, and R60. In this model there were alterations in the p55 and p75 TNF-alpha receptor signaling in...

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Identifiers

PMID: 9848725
DOI: 10.1089/thy.1998.8.1065

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TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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