Article
The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1999
Halvorson L M, Kaiser U B, Chin W W
Abstract excerpt
Expression of the LHbeta gene has been shown to be modulated by both the orphan nuclear receptor, steroidogenic factor-1 (SF-1), and the early growth response protein 1, Egr-1. It is also well known that LHbeta mRNA levels are increased after hormonal activation of the protein kinase C (PKC) signaling system, for example by GnRH; however, the mechanisms by which the PKC system exerts this effect has not been...
Topics
- Animals
- Binding Sites
- Cell Nucleus
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Enzyme Activation
- Fushi Tarazu Transcription Factors
- Gene Expression Regulation
- Gonadotropin-Releasing Hormone
- Homeodomain Proteins