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Article

A defect in GTP synthesis affects mannose outer chain elongation in Saccharomyces cerevisiae.

Molecular & general genetics : MGG - 1 Nov 1997

Shimma Y, Nishikawa A, bin Kassim B, Eto A, Jigami Y

Abstract excerpt

We have found that yeast mutants that are defective in mannose outer chain elongation of N-linked glycoproteins show higher cell wall porosity than normal cells, and are hypersensitive to antibiotics with a large molecular weight; such as neomycin and geneticin. Wild-type yeast cells also showed enhanced sensitivity to neomycin in the presence of tunicamycin, an inhibitor of N-glycosylation, suggesting that the...

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Source

Identifiers

PMID: 9413430
DOI: 10.1007/s004380050591

Genes

ALG1
GUK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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