Article
Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p.
Genetics - 1 Nov 2005
Belanger Kenneth D, Gupta Amitabha, MacDonald Kristy M, Ott Christina M, Hodge Christine A, Cole Charles M, Davis Laura I
Abstract excerpt
The regulated transport of proteins across the nuclear envelope occurs through nuclear pore complexes (NPCs), which are composed of >30 different protein subunits termed nucleoporins. While some nucleoporins are glycosylated, little about the role of glycosylation in NPC activity is understood. We have identified loss-of-function alleles of ALG12, encoding a mannosyltransferase, as suppressors of a...
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