Article
Defect in cell wall integrity of the yeast saccharomyces cerevisiae caused by a mutation of the GDP-mannose pyrophosphorylase gene VIG9.
Bioscience, biotechnology, and biochemistry - 1 Sept 2000
Yoda K, Kawada T, Kaibara C, Fujie A, Abe M, Hitoshi, Hashimoto, Shimizu J, Tomishige N, Noda Y, Yamasaki M
Abstract excerpt
The Saccharomyces cerevisiae VIG9 gene encodes GDP-mannose pyrophosphorylase, which synthesizes GDP-mannose from GTP and mannose-1-phosphate. Although the null mutant was lethal, the vig9 mutants so far obtained showed no growth defect but immature protein glycosylation and drug hypersensitivity. During our search for cell-wall mutants, we found a novel temperature-sensitive mutant, JS30, which required an...
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