Article
Factor V Leiden and thermolabile methylenetetrahydrofolate reductase in extreme old age.
Thrombosis and haemostasis - 1 Nov 1997
Rees D C, Liu Y T, Cox M J, Elliott P, Wainscoat J S
Abstract excerpt
Both factor V Leiden and the C677T methylenetetrahydrofolate reductase (MTHFR) gene mutation are associated with premature vascular disease, and yet are found at surprisingly high allele frequencies in European populations, 2.7% and 35% respectively. We have investigated the prevalence of these mutations in 87 UK residents over the age of ninety, to look for any evidence of their association with premature death....
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