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Article

Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age.

European journal of clinical investigation - 1 Dec 1999

Todesco L, Angst C, Litynski P, Loehrer F, Fowler B, Haefeli W E

Abstract excerpt

BACKGROUND: Elevated fasting levels of total homocysteine are now accepted as an independent risk factor for the development of arteriosclerotic vascular diseases. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), caused by the C677T point mutation, leads to increased thermolability of the enzyme, with reduced enzyme activity. We studied the frequency of this mutation in different...

Read the complete abstract on PubMed

Topics

Adult
Aged
Aging
Arteriosclerosis
Gene Frequency
Genotype
Homocysteine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Oxidoreductases Acting on CH-NH Group Donors

Point Mutation

Polymorphism, Genetic

Source

Identifiers

PMID: 10583447
DOI: 10.1046/j.1365-2362.1999.00578.x

Genes

MTHFR
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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