Article
Methylene tetrahydrofolate reductase C677T genotype and stroke.
Clinical and laboratory haematology - 1 Dec 1998
Salooja N, Catto A, Carter A, Tudenham E G, Grant P J
Abstract excerpt
High levels of homocysteine are associated with atherosclerosis. A thermolabile form of the enzyme methylene tetrahydrofolate reductase (MTHFR) has been proposed as a major cause of a genetic predisposition to hyperhomocysteinaemia and a point mutation at nucleotide 677 of the MTHFR gene causing...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cerebrovascular Disorders
- Cytosine
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Oxidoreductases Acting on CH-NH Group Donors
- Point Mutation
- Risk Factors
- Thymine
- United Kingdom