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Article

Methylene tetrahydrofolate reductase C677T genotype and stroke.

Clinical and laboratory haematology - 1 Dec 1998

Salooja N, Catto A, Carter A, Tudenham E G, Grant P J

Abstract excerpt

High levels of homocysteine are associated with atherosclerosis. A thermolabile form of the enzyme methylene tetrahydrofolate reductase (MTHFR) has been proposed as a major cause of a genetic predisposition to hyperhomocysteinaemia and a point mutation at nucleotide 677 of the MTHFR gene causing a thermolabile MTHFR has been described. We looked for this mutation in 271 patients with CT proven cerebrovascular...

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Source

Identifiers

PMID: 9951581
DOI: 10.1046/j.1365-2257.1998.00158.x

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Methylene tetrahydrofolate reductase C677T genotype and stroke.PMID 9951581Read ↗

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C677T and A1298C methylenetetrahydropholate reductase (MTHFR) polymorphisms as factors involved in ischemic stroke.Semantic proximity Read ↗

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MTHFR C677T gene mutation as a risk factor for arterial stroke: a hospital based study.Semantic proximity Read ↗

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Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis.Semantic proximity Read ↗

Homocysteine, MTHFR 677C→T polymorphism, and risk of ischemic stroke: Results of a meta-analysisSemantic proximity Read ↗

Mutation in the methylenetetrahydrofolate reductase gene might be a risk factor for cerebrovascular disease in peripartum and under oral contraceptive use.Semantic proximity Read ↗

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