Article
Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1999
Harmon D L, Doyle R M, Meleady R, Doyle M, Shields D C, Barry R, Coakley D, Graham I M, Whitehead A S
Abstract excerpt
Mild hyperhomocysteinemia is a risk factor for atherosclerotic vascular disease. Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, an...
Topics
- Aged
- Brain Ischemia
- Cerebrovascular Disorders
- Drug Stability
- Female
- Gene Frequency
- Genetic Variation
- Genotype
- Homozygote
- Hot Temperature
- Humans
- Male
- Methylenetetrahydrofolate Dehydrogenase (NAD+)
- Oxidoreductases
- Reference Values
- Risk Factors