Article
Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1999
Harmon D L, Doyle R M, Meleady R, Doyle M, Shields D C, Barry R, Coakley D, Graham I M, Whitehead A S
Abstract excerpt
Mild hyperhomocysteinemia is a risk factor for atherosclerotic vascular disease. Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations. The purpose of this study was to...
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