Article
A common methylenetetrahydrofolate reductase gene mutation and longevity.
Atherosclerosis - 1 Dec 1998
Brattström L, Zhang Y, Hurtig M, Refsum H, Ostensson S, Fransson L, Jonés K, Landgren F, Brudin L, Ueland P M
Abstract excerpt
Homozygotes (TT genotype) for the C677T mutation in the gene of methylenetetrahydrofolate reductase (C677T/MTHFR mutation) constitute about 12% of the Caucasian population. They have mild hyperhomocysteinemia which is an established risk factor for cardiovascular disease. If the mutation is associated with premature death its prevalence is expected to be lower in the elderly than in the young. To test this we...
Topics
- Aged
- Aged, 80 and over
- Cardiovascular Diseases
- Female
- Gene Frequency
- Genotype
- Homozygote
- Humans
- Hyperhomocysteinemia
- Infant, Newborn
- Longevity
- Male