Article
Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA.
Virology - 24 Nov 1997
Günther S, Sommer G, Iwanska A, Will H
Abstract excerpt
Defective hepatitis B virus (HBV) genomes derived from packaging and reverse transcription of spliced RNA pregenomes were reported to be associated with progression to chronic infection. Since only two types with similarly spliced regions were characterized so far we reasoned that additional "spliced" genome variants may exist. Therefore, we isolated a large number of defective HBV genomes from sera of seven...
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