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Hepatitis B virus spliced variants are associated with an impaired response to interferon therapy

20 Nov 2015

Abstract excerpt

During hepatitis B virus (HBV) replication, spliced HBV genomes and splice-generated proteins have been widely described, however, their biological and clinical significance remains to be defined. Here, an elevation of the proportion of HBV spliced variants in the sera of patients with chronic hepatitis B (CHB) is shown to correlate with an impaired respond to interferon-α (IFN-α) therapy. Transfection of the...

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PMID: 26585041
DOI: 10.1038/srep16459

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