Article
Identification of a unique splicing regulatory cluster in hepatitis B virus pregenomic RNA.
FEBS letters - 20 Oct 2011
Chowdhury Joydip Bhanja, Roy Dipika, Ghosh Sagarmoy
Abstract excerpt
HBV particles with genome derived from spliced mRNAs accumulate in patients with virus-derived severe liver necrosis and fibrosis. We investigated the role of an intronic element (intronic splicing silencer-long, ISS(L)) on splicing of HBV minigene transcripts. Removal of the entire ISS(L) showed two-fold increase in splicing while shorter deletions within ISS(L) indicated isolated clusters of activator and...
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