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Article

Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.

Hepatology (Baltimore, Md.) - 1 Sept 2008

Preiss Scott, Littlejohn Margaret, Angus Peter, Thompson Alex, Desmond Paul, Lewin Sharon R, Sasadeusz Joe, Matthews Gail, Dore Gregory J, Shaw Tim, Sozzi Vitini, Yuen Lilly, Lau George, Ayres Anna, Thio Chloe, Avihingsanon Anchalee, Ruxrungtham Kiat, Locarnini Stephen, Revill Peter A

Abstract excerpt

UNLABELLED: Defective hepatitis B virus DNA (dDNA) is reverse-transcribed from spliced hepatitis B virus (HBV) pregenomic messenger RNA (pgRNA) and has been identified in patients with chronic HBV (CH-B). The major 2.2-kb spliced pgRNA encodes a novel HBV gene product, the hepatitis B splice prot...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18571815
DOI: 10.1002/hep.22386
PMCID: PMC2669111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18571815-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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