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Article

High serum levels of pregenomic RNA reflect frequently failing reverse transcription in hepatitis B virus particles.

Virology journal - 15 May 2018

Prakash Kasthuri, Rydell Gustaf E, Larsson Simon B, Andersson Maria, Norkrans Gunnar, Norder Heléne, Lindh Magnus

Abstract excerpt

BACKGROUND: Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in serum of infected individuals, and quantification of this HBV RNA could be clinically useful. METHODS: In a retrospective study of 95 patients with chronic HBV infection, we characterised HBV...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29764511
DOI: 10.1186/s12985-018-0994-7
PMCID: PMC5952638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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