A double-spliced defective hepatitis B virus genome derived from hepatocellular carcinoma tissue enhanced replication of full-length virus.

doi:10.1002/jmv.21393

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Article

A double-spliced defective hepatitis B virus genome derived from hepatocellular carcinoma tissue enhanced replication of full-length virus.

Journal of medical virology - 1 Feb 2009

Ma Zhang-Mei, Lin Xu, Wang Yong-Xiang, Tian Xiao-Chen, Xie You-Hua, Wen Yu-Mei

Abstract excerpt

In hepatitis B virus (HBV) replication cycle, pregenomic RNA undergoes splicing and the reverse transcribed defective genomes can be packaged and released. Various types of spliced defective HBV genomes have been isolated from the sera and liver tissues of viral hepatitis B patients. To explore the functions of a 2.2 kb double spliced HBV variant, a 3.2 kb full-length HBV isolate (#97-34) and its 2.2 kb...

Topics

Carcinoma, Hepatocellular
Cell Line
Culture Media
DNA, Viral
Defective Viruses
Genome, Viral
Genotype
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B e Antigens
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver Neoplasms

Male

Molecular Sequence Data

RNA Splicing

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 19107969
DOI: 10.1002/jmv.21393

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