Article
Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment.
Experimental neurology - 1 Nov 1997
Ishiyama T, Klinkosz B, Pioro E P, Mitsumoto H
Abstract excerpt
Preclinical diagnosis of motor neuron disease (MND) in the wobbler mouse (wr/wr) has been impossible until recently. However, with the development of a new hybrid, the C57BL/6J x New Zealand Black (B6NZB) wr/wr mouse, the polymerase chain reaction (PCR) can be used to establish the preclinical di...
Topics
- Animals
- Brain-Derived Neurotrophic Factor
- Ciliary Neurotrophic Factor
- Disease Models, Animal
- Disease Progression
- Drug Evaluation, Preclinical
- Drug Therapy, Combination
- Female
- Genes, Recessive
- Genotype
- Hybridization, Genetic