Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.

doi:10.1016/0301-0082(94)90071-x

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Article

Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.

Progress in neurobiology - 1 Feb 1994

Jockusch H, Kaupmann K, Gronemeier M, Schleef M, Klocke R

Abstract excerpt

Any biological structure can be studied using mutations that interfere either with its emergence or its function. We investigate spontaneous and induced mutations in the mouse that affect neuromuscular development and function. The wobbler mouse (phenotype WR, genotype wr/wr) suffers from muscula...

Topics

Animals
Humans
Mice
Mice, Neurologic Mutants
Muscles
Muscular Atrophy, Spinal
Mutation
Myotonia
Nervous System

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