Article
Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens.
Mutation research - 17 Dec 1999
Casciano D A, Aidoo A, Chen T, Mittelstaedt R A, Manjanatha M G, Heflich R H
Abstract excerpt
Much of the progress in the field of cancer research has come from the increased understanding of the molecular events associated with the initiation and accumulation of mutational events associated with carcinogenesis. Genetic toxicologists have developed a number of in vitro and in vivo non-mammalian and mammalian systems to predict those genetic events required to induce the cancer process. Several model...
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