Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

doi:10.1038/sj.onc.1201832

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Article

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

Oncogene - 25 Jun 1998

Maier D, Zhang Z, Taylor E, Hamou M F, Gratzl O, Van Meir E G, Scott R J, Merlo A

Abstract excerpt

The 10q25-26 region between the dinucleotide markers D10S587 and D10S216 is deleted in glioblastomas and, as we have recently shown, in low-grade oligodendrogliomas. We further refined somatic mapping on 10q23-tel and simultaneously assessed the role of the candidate tumor suppressor gene PTEN/MM...

Topics

Amino Acid Substitution
Chromosome Mapping
Chromosomes, Human, Pair 10
DNA, Neoplasm
Dinucleotide Repeats
Gene Deletion
Genes, Tumor Suppressor
Genetic Markers
Glioma
Humans
Loss of Heterozygosity
Mutation
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatases

Sequence Analysis, DNA

Severity of Illness Index

Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9681833
DOI: 10.1038/sj.onc.1201832

Genes

PTEN
DMBT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9681833-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.