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Article

Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma?

Neurosurgical review - 1 Jul 2001

Rustia A, Wierzbicki V, Marrocco L, Tossini A, Zamponi C, Lista F

Abstract excerpt

Chromosome 10 deletions are among the most common genetic changes in highly malignant glial tumors. It has been noted that loss of heterozygosity (LOH) at 10q23 is a frequent alteration in a variety of human tumors and occurs in approximately 70% of all glioblastomas. By mapping of homozygous deletions on 10q23, a candidate tumor suppressor gene has been isolated, called PTEN for "phosphatase and tensin homolog...

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Source

Identifiers

PMID: 11485247
DOI: 10.1007/pl00014589

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma?PMID 11485247Read ↗

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.Semantic proximity Read ↗

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.Semantic proximity Read ↗

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