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Article

A point mutation in the MET oncogene abrogates metastasis without affecting transformation

9 Dec 1997

Abstract excerpt

The MET oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF), known to stimulate invasive growth of epithelial cells. MET is overexpressed in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis. To investigate whether this oncogene is directly responsible for the acquisition of the metastatic phenotype,...

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Identifiers

PMID: 9391119
DOI: 10.1073/pnas.94.25.13868

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A point mutation in the MET oncogene abrogates metastasis without affecting transformationPMID 9391119Read ↗

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